Syntropa

Open science · consortium discovery

Find the community that closes the loop

Many useful metabolic routes are not one organism's job. Syntropa harmonizes thousands of genome-scale models into one queryable corpus, then searches it for consortia: communities whose members feed each other toward products that are hard for any single organism to reach alone. Often the honest answer is a single organism: Syntropa runs the consortium search, reports when a partner adds nothing, and publishes the negative. Most worked examples are honest single-organism results.

What you can do here

Browse the atlas

open · no account

What the corpus contains and, just as importantly, what it cannot express: source mix, phyla, oxygen niche, biosafety tier, and per-source licensing.

Open the atlas →

Read the Gap Report

open · no account

A map of what to build next: which two-step relay routes the corpus can already test, and which it cannot reach. Counted route by route with the upper bound stated plainly, starting with a zero Syntropa published that turned out to be wrong.

Read the Gap Report →

Read discovery reports

open · no account

Worked examples with the full funnel: candidate consortia, cross-feeding, the flux-balance verdict, the thermodynamic gate, and every drop reason.

See reports →

Get the data

open · cite it

The corpus is a versioned, content-hashed dataset with a citable Zenodo DOI, so a result can be traced to the exact corpus that produced it.

Data & licensing →

Get a run on your target

coming soon

The hosted discovery service is in development. Register for the launch note and you will hear when it opens. The preprint and the open corpus already have citable DOIs.

Register interest →

How it stays honest

Every discovery claim (feasibility, free-energy sanity, carbon balance) is computed, not asserted: flux-balance analysis for stoichiometric feasibility, a carbon-conservation audit as the result-level filter (carbon only, since redox/electron balance and per-candidate free energy are not yet enforced; see the reports), and a class-level, necessary-condition thermodynamic gate (a sanity check on net free energy, not a per-candidate proof). When a gate cannot decide, it says unknown rather than guessing.

And the limits are published with the results: flux balance proves stoichiometric possibility, not biological reality. Nothing here has been cultured yet. Every candidate is a hypothesis, which is precisely why Syntropa publishes what is missing, so someone can go and test it.